Lei Fang

Abstract: We present the design and performance evaluation of an all-digital brain PET system optimized for high-resolution and dynamic neuroimaging. The system features a transaxial and axial field-of-view of 320 mm and 255 mm, respectively, and comprises a 6 × 6 array of detector modules. Each module integrates 3.9 mm × 3.9 mm × 20 mm lutetium-yttrium oxyorthosilicate (LYSO) crystals coupled one-to-one with silicon photomultipliers (SiPM). Detector signals are individually digitized using a multi-voltage threshold (MVT) scheme, enabling precise signal sampling and high count-rate performance. The system achieves an average sensitivity of 22.1 cps/kBq and a peak noise equivalent count rate (NECR) of 150.9 kcps. Phantom studies demonstrate a spatial resolution of 2.0 mm. In human brain imaging, the system provides high image quality and supports dynamic acquisition with temporal resolution as short as 2 s per frame, enabling visualization of regional tracer uptake and vascular dynamics.

Speaker: Mr. Lei Fang is a PhD student at Huazhong University of Science and Technology (HUST). He has been dedicated to the research and development of all-digital PET systems for over 17 years. He led the development of the world’s first clinical all-digital PET system, recognized as a National Innovative Medical Device, and the first brain-dedicated all-digital PET system with independent intellectual property rights. He has overseen the approval of nine Class III medical device registration certificates and built a high-performance product portfolio. His work has been recognized among China’s Top 10 Sci-Tech News Events and Major Medical Advances in 2019. He has filed over 70 patents and published more than 10 high-impact papers.