Liudmila Yakubova

Abstract: Chronic stress plays a significant role in the development of arterial hypertension (AH), being a significant modifiable cardiovascular risk factor and a target for intervention. Chronic stress, in turn, often causes sleep disturbances. Psychoemotional disturbances in the early stages of AH may reflect not only vascular damage to the brain but also be a manifestation of stress-related neuroinflammatory processes in the hippocampus. Impaired glymphatic clearance is a key link between stress, inflammation, and brain dysfunction. The modern model of metabolite removal from the central nervous system or the “lymphatic drainage system of the brain” is represented by the functionally interconnected glymphatic system and meningeal lymphatic vessels. Despite a clear understanding of the general anatomy, the role of the "lymphatic drainage system of the brain" in the context of cerebroprotection remains poorly understood.
The purpose of my presentation is to provide an overview of the accumulated research findings on the relationship between chronic stress, hypertension, sleep disorders, and the role of glymphatic dysfunction as a key factor in the development of these diseases.
The report will examine the main mechanisms of impaired glymphatic clearance: neuroendocrine (hypercortisolemia and astrocyte atrophy), vascular (endothelial dysfunction, reduction of arterial pulsation and increased arterial stiffening), and inflammatory (microglial activation and release of pro-inflammatory cytokines). Special attention is paid to the formation of three self-perpetuating vicious cycles: «stress → impaired glymphatic clearance → hippocampal damage → increased stress»; «AH → reduction of arterial pulsation → glymphatic dysfunction → AH progresses»; and «insomnia → toxin accumulation → locus coeruleus damage → aggravation of sleep disorders».
Photobiomodulation, a non-invasive treatment using red and infrared light, is considered a promising therapeutic approach. Results from pilot clinical trials have now been published, confirming the positive impact of this therapy on cognitive function, emotional status, and sleep quality. Accumulated research data indicates the potential and innovative nature of photobiomodulation in the comprehensive treatment of a number of conditions and may be useful in the treatment of sleep disorders, AH and chronic stress.

Speaker: Liudmila Yakubova - Head of general practitioner and policlinic therapy department in Grodno State Medical University, Professor, MD, PhD. Author of more than 350 publications. Profiles and identifiers: ORCID https://orcid.org/0000-0001-7632-9695

Qualification:

• awarded the degree of PhD 2007,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, he was awarded the academic title of Associate Professor in 2011,
• By the decision of the Presidium of the Higher Attestation Commission of the Republic of Belarus, the degree of Doctor of Medical Sciences was awarded in 2020,he was awarded the academic title of professor in 2021.

I had been the leader or scientific performer of several funded research projects: "Develop and implement a method for the treatment of coronary heart disease and osteoporosis by influencing the general mechanisms of their development", (2011-2013).

“To develop and implement a new method of secondary prevention and treatment of lesions of the cardiovascular system in case of deficiency /vitamin D deficiency in people with arterial hypertension» (2013-2015). "Identification of risk groups for D-vitamin deficiency", (2013-2015).

“Research on the impact of palm oil on the health of the population of the Republic of Belarus and the establishment of acceptable medical and biological levels of palm oil consumption” (2017-2018 ). Grant of the President of the Republic of Belarus (2019) for the development and implementation in general medical practice of recommendations for identifying risk factors, diagnosing and correcting D-hypovitaminosis, the use of which will help increase the primary prevention of vitamin D-associated diseases among residents of the Republic of Belarus.

"To develop new types of chocolate products enriched with protein, calcium and vitamin D, providing an increase in the balance of nutrition of preschool and school children" (2016-2020).

Research work on the project of cross-border cooperation No. RVI 1/0326/16 "Model of the medical program to combat osteoporosis in the Polish-Belarusian border area" (2018-2021).

«Develop and implement a method for assessing the risk of development and progression of atrial fibrillation in patients with arterial hypertension» (2021-2024).